Protein profile

PA4206

resistance-nodulation-cell division (RND) efflux membrane fusion protein

Genome: NC_002516.2

Gene: mexH PA4206 Structure source: AlphaFold UniProt Q9HWH5
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Amino acids 370
Annotations 5
Features 19
PDB binders 0
Druggability 0.608

Overview

Basic information about this protein and its source genome.

Accession
PA4206
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
mexH PA4206
Status
annotated
Amino acids
370
Structure source
AlphaFold
GO
GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.608
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
  • GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
108 128 Coils Coil Coil
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
5 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
99 164 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
58 272 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
69 190 Gene3D G3DSA:2.40.50.100 -
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
43 352 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
43 352 InterPro IPR006143 RND efflux pump, membrane fusion protein
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
273 362 Gene3D G3DSA:2.40.420.20 -
9 356 PANTHER PTHR30469 MULTIDRUG RESISTANCE PROTEIN MDTA
21 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
187 272 FunFam G3DSA:2.40.30.170:FF:000010 Efflux RND transporter periplasmic adaptor subunit
25 370 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
191 272 Gene3D G3DSA:2.40.30.170 -
65 267 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
65 267 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4206
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.608
4 0.416
2 0.352
3 0.286