Protein profile

PA4221

Fe(III)-pyochelin outer membrane receptor

Genome: NC_002516.2

Gene: fptA PA4221 Structure source: Experimental + AlphaFold UniProt P42512
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Amino acids 720
Annotations 7
Features 24
PDB binders 9
Druggability 0.83

Overview

Basic information about this protein and its source genome.

Accession
PA4221
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
fptA PA4221
Status
annotated
Amino acids
720
Structure source
Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1903981 Binding to enterobactin. GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0038023 Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0033214 A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores is imported into the cell by transmembrane transport or endocytosis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.83
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:1903981 Binding to enterobactin.
  • GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in).
  • GO:0038023 Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
  • GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0033214 A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores is imported into the cell by transmembrane transport or endocytosis.
  • GO:0015343 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
703 720 ProSitePatterns PS01156 TonB-dependent receptor proteins signature 2.
703 720 InterPro IPR010917 TonB-dependent receptor, conserved site
41 720 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
43 720 SUPERFAMILY SSF56935 Porins
288 717 Pfam PF00593 TonB dependent receptor
288 717 InterPro IPR000531 TonB-dependent receptor-like, beta-barrel
22 33 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
83 182 Gene3D G3DSA:2.170.130.10 -
83 182 InterPro IPR037066 TonB-dependent receptor, plug domain superfamily
78 720 NCBIfam TIGR01783 TonB-dependent siderophore receptor
78 720 InterPro IPR010105 TonB-dependent siderophore receptor
28 720 PANTHER PTHR32552 FERRICHROME IRON RECEPTOR-RELATED
28 720 InterPro IPR039426 TonB-dependent receptor-like
183 720 Gene3D G3DSA:2.40.170.20 -
183 720 InterPro IPR036942 TonB-dependent receptor-like, beta-barrel domain superfamily
1 21 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
21 38 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
54 182 FunFam G3DSA:2.170.130.10:FF:000010 Ferripyoverdine receptor
1 40 Phobius SIGNAL_PEPTIDE Signal peptide region
76 174 Pfam PF07715 TonB-dependent Receptor Plug Domain
76 174 InterPro IPR012910 TonB-dependent receptor, plug domain
82 720 CDD cd01347 ligand_gated_channel
34 40 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 36 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1XKW
X-ray 2.00 Å A
92.4% 56-720
PDBe RCSB PDBj File
Viewing
AlphaFold PA4221
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.83
1 0.58
22 0.224
4 0.211

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 44.38 0.972
2 12.12 0.64
3 9.93 0.534
4 8.3 0.442
5 7.97 0.424

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

59 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
LDA
1XKW 2.00 Å Open crystal
229.4 Da LogP 4.48 TPSA 23.1 ✓ Ro5 ✓ Clean CCCCCCCCCCCC[N+](C)(C)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.