Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4227
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4227 pchR
Status: annotated
Amino acids: 296
Structure source: AlphaFold

GO

GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.761

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MTITIIAPPQADAAAPAPGNRPGVAHIDPNMKLVTGTFCSASEDWFEEPLERGLRLILVQSGQLRCRIPGQPEHLIEGPSLCTIANDGDFTSAQIYGTDKPLRYTIVQLGVEALDSRLGWLPEQLIRRPGGDPRIMSCPAPRAMQALASQIATCQMLGPTRDLYLGGKALELAALSAQFLSGEGRPVEEPRITCSEVERIHAARDLLVGALQEPPSLDTLASRVGMNPRKLTAGFRKVFGASVFGYLQEYRLREAHRMLCDEEANVSTVAYRVGYSPAHFSIAFRKRYGISPSEIR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7

GO:0032993 A macromolecular complex containing both protein and DNA molecules.
GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
201	296	ProSiteProfiles	PS01124	Bacterial regulatory proteins, araC family DNA-binding domain profile.
201	296	InterPro	IPR018060	DNA binding HTH domain, AraC-type
214	296	SMART	SM00342	aracneu4
214	296	InterPro	IPR018060	DNA binding HTH domain, AraC-type
249	296	Gene3D	G3DSA:1.10.10.60	-
251	292	ProSitePatterns	PS00041	Bacterial regulatory proteins, araC family signature.
251	292	InterPro	IPR018062	HTH domain AraC-type, conserved site
250	296	SUPERFAMILY	SSF46689	Homeodomain-like
250	296	InterPro	IPR009057	Homeobox-like domain superfamily
194	248	Gene3D	G3DSA:1.10.10.60	-
2	296	PANTHER	PTHR47893	REGULATORY PROTEIN PCHR
198	248	SUPERFAMILY	SSF46689	Homeodomain-like
198	248	InterPro	IPR009057	Homeobox-like domain superfamily
220	296	Pfam	PF12833	Helix-turn-helix domain
220	296	InterPro	IPR018060	DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4227	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.761
2				0.57

PA4227