Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4234
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: uvrA PA4234
Status: annotated
Amino acids: 945
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009380 Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0009381 Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 31.683
Human E-value: 4.37e-06
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.592

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0009380 Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap.
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0009381 Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind.
GO:0008270 Binding to a zinc ion (Zn).
GO:0006974 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
GO:0006289 A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
GO:0009432 An error-prone process for repairing damaged microbial DNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records

Show feature table

Start	End	DB	Term	Name
4	116	CDD	cd03270	ABC_UvrA_I
319	437	Gene3D	G3DSA:1.10.8.280	-
92	518	Gene3D	G3DSA:1.20.1580.10	ABC transporter ATPase like domain
310	593	ProSiteProfiles	PS50893	ATP-binding cassette, ABC transporter-type domain profile.
310	593	InterPro	IPR003439	ABC transporter-like, ATP-binding domain
607	937	ProSiteProfiles	PS50893	ATP-binding cassette, ABC transporter-type domain profile.
607	937	InterPro	IPR003439	ABC transporter-like, ATP-binding domain
6	569	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
6	569	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
609	937	Gene3D	G3DSA:3.40.50.300	-
609	937	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
291	399	Pfam	PF17755	UvrA DNA-binding domain
291	399	InterPro	IPR041552	UvrA DNA-binding domain
487	501	ProSitePatterns	PS00211	ABC transporters family signature.
487	501	InterPro	IPR017871	ABC transporter-like, conserved site
135	244	FunFam	G3DSA:3.30.190.20:FF:000003	UvrABC system protein A
617	921	CDD	cd03271	ABC_UvrA_II
6	580	Gene3D	G3DSA:3.40.50.300	-
6	580	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
693	830	Gene3D	G3DSA:1.20.1580.10	ABC transporter ATPase like domain
130	237	Pfam	PF17760	UvrA interaction domain
130	237	InterPro	IPR041102	UvrA, interaction domain
1	940	Hamap	MF_00205	UvrABC system protein A [uvrA].
1	940	InterPro	IPR004602	UvrABC system subunit A
693	830	FunFam	G3DSA:1.20.1580.10:FF:000002	UvrABC system protein A
288	404	FunFam	G3DSA:1.10.8.280:FF:000001	UvrABC system protein A
830	844	ProSitePatterns	PS00211	ABC transporters family signature.
830	844	InterPro	IPR017871	ABC transporter-like, conserved site
3	925	NCBIfam	TIGR00630	excinuclease ABC subunit UvrA
3	925	InterPro	IPR004602	UvrABC system subunit A
612	910	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
612	910	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
209	282	Gene3D	G3DSA:3.30.1490.20	-
209	282	InterPro	IPR013815	ATP-grasp fold, subdomain 1
2	942	PANTHER	PTHR43152	UVRABC SYSTEM PROTEIN A

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4234	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
7				0.592
2				0.483

PA4234