Protein profile

PA4236

catalase

Genome: NC_002516.2

Gene: PA4236 katA Structure source: Experimental + AlphaFold UniProt O52762
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Amino acids 482
Annotations 8
Features 34
PDB binders 5
Druggability 0.684

Overview

Basic information about this protein and its source genome.

Accession
PA4236
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4236 katA
Status
annotated
Amino acids
482
Structure source
Experimental + AlphaFold
EC
1.11.1.6
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion. GO:0042744 The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). GO:0042542 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
65.517
Human E-value
6.07e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.684
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MEEKTRLTTAAGAPVVDNQNVQTAGPRGPMLLQDVWFLEKLAHFDREVIPERRMHAKGSAAYGTFTVTHDITPYTRAKIFSQVGKKTDMFLRFSTVAGERGAADAERDIRGFSMRFYTEQGNWDLVGNNTPVFYLRDPLKFPDLNHVVKRDPRTNLRNATFKWDFFSHLPESLHQLTIDFSDRGLPKSYRHIHGFGSHTFSFINANNERFWVKFHFKTQQGIENLTNAEAAEVIAQDRESSQRDLYESIEKGDFPRWKMYVQIMPEKEAATYRYNPFDLTKVWPHGDYPLIEVGFFELNRNPDNYFAEVEQAAFTPANVVPGIGFSPDKMLQGRLFSYGDAHRYRLGVNHHQIPVNAARCPHQVYHRDGGMRVDGNNAHQRVTYEPNSFNQWQEQPDFSEPPLSLEGAADHWNHRVDDDYYSQPAALFHLFTDEQKQRLFANIAEDIRDVPEQIQRRQIGLFLKVDPAYGKGVADALGLKLD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0046872 Binding to a metal ion.
  • GO:0042744 The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
  • GO:0042542 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
  • GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
8 390 Pfam PF00199 Catalase
334 342 ProSitePatterns PS00437 Catalase proximal heme-ligand signature.
334 342 InterPro IPR002226 Catalase haem-binding site
8 393 SMART SM01060 Catalase_2
8 393 InterPro IPR011614 Catalase core domain
44 60 ProSitePatterns PS00438 Catalase proximal active site signature.
44 60 InterPro IPR024708 Catalase active site
321 347 PRINTS PR00067 Catalase signature
321 347 InterPro IPR018028 Catalase, mono-functional, haem-containing
124 142 PRINTS PR00067 Catalase signature
124 142 InterPro IPR018028 Catalase, mono-functional, haem-containing
289 316 PRINTS PR00067 Catalase signature
289 316 InterPro IPR018028 Catalase, mono-functional, haem-containing
84 102 PRINTS PR00067 Catalase signature
84 102 InterPro IPR018028 Catalase, mono-functional, haem-containing
21 44 PRINTS PR00067 Catalase signature
21 44 InterPro IPR018028 Catalase, mono-functional, haem-containing
105 122 PRINTS PR00067 Catalase signature
105 122 InterPro IPR018028 Catalase, mono-functional, haem-containing
3 482 FunFam G3DSA:2.40.180.10:FF:000001 Catalase
3 477 PANTHER PTHR11465 CATALASE
3 477 InterPro IPR018028 Catalase, mono-functional, haem-containing
1 482 PIRSF PIRSF038928 Catalase_clade1-3
1 482 InterPro IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3
4 482 ProSiteProfiles PS51402 catalase family profile.
4 482 InterPro IPR018028 Catalase, mono-functional, haem-containing
3 481 SUPERFAMILY SSF56634 Heme-dependent catalase-like
3 481 InterPro IPR020835 Catalase superfamily
48 477 CDD cd08156 catalase_clade_3
48 477 InterPro IPR040333 Catalase, clade 3
418 477 Pfam PF06628 Catalase-related immune-responsive
418 477 InterPro IPR010582 Catalase immune-responsive domain
8 390 InterPro IPR011614 Catalase core domain
3 482 Gene3D G3DSA:2.40.180.10 Catalase core domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4E37
X-ray 2.53 Å A,B,C,D
99.6% 3-482
PDBe RCSB PDBj File
Viewing
AlphaFold PA4236
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.684

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 57.87 0.986
2 16.82 0.788
3 6.16 0.306
4 4.57 0.196
5 1.59 0.025

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

6 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3TR
1TH4
P00432 84.1 Da LogP -0.61 TPSA 67.6 ✓ Ro5 ✓ Clean c1[nH]nc(n1)N
AZI
1TH2
P00432 42.0 Da LogP 0.87 TPSA 58.7 ✓ Ro5 Alert [N-]=[N+]=[N-]
NH3
3RGS
P00432 17.0 Da LogP 0.16 TPSA 35.0 ✓ Ro5 ✓ Clean N
O
1GWF
P29422 18.0 Da LogP -0.82 TPSA 31.5 ✓ Ro5 ✓ Clean O
OXY
1QWL
P77872 32.0 Da LogP 0.07 TPSA 34.1 ✓ Ro5 ✓ Clean O=O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.