Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4271
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: rplL PA4271
Status: annotated
Amino acids: 122
Structure source: AlphaFold

GO

GO:0022625 The large subunit of a ribosome located in the cytosol. GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.426

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0022625 The large subunit of a ribosome located in the cytosol.
GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
2	51	Gene3D	G3DSA:1.20.5.710	Single helix bin
2	51	InterPro	IPR036235	Ribosomal protein L7/L12, oligomerisation domain superfamily
3	121	CDD	cd00387	Ribosomal_L7_L12
3	121	InterPro	IPR000206	Ribosomal protein L7/L12
56	122	Pfam	PF00542	Ribosomal protein L7/L12 C-terminal domain
56	122	InterPro	IPR013823	Ribosomal protein L7/L12, C-terminal
52	122	Gene3D	G3DSA:3.30.1390.10	-
52	122	InterPro	IPR014719	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
2	52	FunFam	G3DSA:1.20.5.710:FF:000003	50S ribosomal protein L7/L12
52	122	FunFam	G3DSA:3.30.1390.10:FF:000001	50S ribosomal protein L7/L12
51	122	SUPERFAMILY	SSF54736	ClpS-like
51	122	InterPro	IPR014719	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
4	50	Pfam	PF16320	Ribosomal protein L7/L12 dimerisation domain
4	50	InterPro	IPR008932	Ribosomal protein L7/L12, oligomerisation
2	122	Hamap	MF_00368	50S ribosomal protein L7/L12 [rplL].
2	122	InterPro	IPR000206	Ribosomal protein L7/L12
102	122	Coils	Coil	Coil
4	58	SUPERFAMILY	SSF48300	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
4	58	InterPro	IPR036235	Ribosomal protein L7/L12, oligomerisation domain superfamily
1	122	NCBIfam	TIGR00855	50S ribosomal protein L7/L12
1	122	InterPro	IPR000206	Ribosomal protein L7/L12
7	121	PANTHER	PTHR45987	39S RIBOSOMAL PROTEIN L12
7	121	InterPro	IPR000206	Ribosomal protein L7/L12

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4271	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.426

PA4271