Protein profile

PA4278

hypothetical protein

Genome: NC_002516.2

Gene: PA4278 Structure source: AlphaFold UniProt Q9HWC2
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Amino acids 234
Annotations 1
Features 16
PDB binders 0
Druggability 0.448

Overview

Basic information about this protein and its source genome.

Accession
PA4278
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4278
Status
annotated
Amino acids
234
Structure source
AlphaFold
GO
GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.448
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
28 234 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
73 154 ProSiteProfiles PS51724 SPOR domain profile.
73 154 InterPro IPR007730 Sporulation-like domain
80 148 SUPERFAMILY SSF110997 Sporulation related repeat
80 148 InterPro IPR036680 Sporulation-like domain superfamily
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
157 223 SUPERFAMILY SSF110997 Sporulation related repeat
157 223 InterPro IPR036680 Sporulation-like domain superfamily
77 150 Gene3D G3DSA:3.30.70.1070 Sporulation related repeat
77 150 InterPro IPR036680 Sporulation-like domain superfamily
78 148 Pfam PF05036 SPOR domain
78 148 InterPro IPR007730 Sporulation-like domain
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
16 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4278
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.448
1 0.378
2 0.307