Protein profile

PA4285

exodeoxyribonuclease V subunit gamma

Genome: NC_002516.2

Gene: recC PA4285 Structure source: AlphaFold UniProt Q9HWB5
Export view
Amino acids 1171
Annotations 7
Features 24
PDB binders 0
Druggability 0.606

Overview

Basic information about this protein and its source genome.

Accession
PA4285
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
recC PA4285
Status
annotated
Amino acids
1171
Structure source
AlphaFold
GO
GO:0009338 An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003678 Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0008854 Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.606
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0009338 An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003678 Unwinding of a DNA helix, driven by ATP hydrolysis.
  • GO:0008854 Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0000724 The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
16 279 Gene3D G3DSA:3.40.50.10930 -
13 1171 PIRSF PIRSF000980 RecC
13 1171 InterPro IPR006697 RecBCD enzyme subunit RecC
14 372 Pfam PF04257 Exodeoxyribonuclease V, gamma subunit
14 1128 NCBIfam TIGR01450 exodeoxyribonuclease V subunit gamma
14 1128 InterPro IPR006697 RecBCD enzyme subunit RecC
389 826 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
389 826 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
889 966 Gene3D G3DSA:1.10.10.990 -
107 213 Gene3D G3DSA:1.10.10.160 -
107 213 InterPro IPR013986 DExx box DNA helicase domain superfamily
856 1099 Pfam PF17946 RecC C-terminal domain
856 1099 InterPro IPR041500 RecC, C-terminal
14 1170 PANTHER PTHR30591 RECBCD ENZYME SUBUNIT RECC
841 1163 SUPERFAMILY SSF52980 Restriction endonuclease-like
841 1163 InterPro IPR011335 Restriction endonuclease type II-like
355 535 Gene3D G3DSA:3.40.50.300 -
355 535 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
654 833 Gene3D G3DSA:3.40.50.300 -
654 833 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
13 1166 Hamap MF_01486 RecBCD enzyme subunit RecC [recC].
13 1166 InterPro IPR006697 RecBCD enzyme subunit RecC
13 374 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
13 374 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4285
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.458
23 0.377
43 0.278
19 0.268