Protein profile

PA4299

type II secretion system protein TadD

Genome: NC_002516.2

Gene: tadD Structure source: ColabFold
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Amino acids 245
Annotations 1
Features 17
PDB binders 0
Druggability 0.615

Overview

Basic information about this protein and its source genome.

Accession
PA4299
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
tadD
Status
annotated
Amino acids
245
Structure source
ColabFold
GO
GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.615
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
212 245 MobiDBLite mobidb-lite consensus disorder prediction
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
184 204 Coils Coil Coil
20 245 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
3 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 245 PIRSF PIRSF029658 UCP029658_TPR
1 245 InterPro IPR016931 Uncharacterised conserved protein UCP029658, TPR
100 133 ProSiteProfiles PS50005 TPR repeat profile.
100 133 InterPro IPR019734 Tetratricopeptide repeat
27 214 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
27 214 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
1 17 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
53 202 SUPERFAMILY SSF48452 TPR-like
53 202 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold PA4299
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.615