Protein profile

PA4303

hypothetical protein

Genome: NC_002516.2

Gene: tadZ PA4303 Structure source: Experimental + AlphaFold UniProt Q9HW97
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Amino acids 394
Annotations 4
Features 7
PDB binders 0
Druggability 0.238

Overview

Basic information about this protein and its source genome.

Accession
PA4303
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
tadZ PA4303
Status
annotated
Amino acids
394
Structure source
Experimental + AlphaFold
GO
GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.238
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
149 373 Gene3D G3DSA:3.40.50.300 -
149 373 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 133 Pfam PF16968 Pilus assembly protein TadZ N-terminal
1 133 InterPro IPR031580 Pilus assembly protein TadZ, N-terminal
1 130 Gene3D G3DSA:3.40.50.2300 -
150 372 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
150 372 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4LDA
X-ray 2.40 Å A,B,C,D,E,F,G,H
33.0% 1-130
PDBe RCSB PDBj File
Viewing
AlphaFold PA4303
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.238