Protein profile

PA4307

chemotactic transducer PctC

Genome: NC_002516.2

Gene: pctC PA4307 Structure source: Experimental + AlphaFold UniProt Q9HW93
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Amino acids 632
Annotations 6
Features 42
PDB binders 1
Druggability 0.958

Overview

Basic information about this protein and its source genome.

Accession
PA4307
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pctC PA4307
Status
annotated
Amino acids
632
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0043200 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.958
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0043200 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records
Show feature table
Start End DB Term Name
301 632 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
55 275 Gene3D G3DSA:3.30.450.20 PAS domain
305 632 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
438 458 Coils Coil Coil
304 350 CDD cd06225 HAMP
407 427 MobiDBLite mobidb-lite consensus disorder prediction
66 177 FunFam G3DSA:3.30.450.20:FF:000048 Methyl-accepting chemotaxis protein
323 632 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
282 304 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
177 631 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
11 30 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
301 355 SMART SM00304 HAMP_11
301 355 InterPro IPR003660 HAMP domain
390 450 SMART SM00304 HAMP_11
390 450 InterPro IPR003660 HAMP domain
181 268 CDD cd12912 PDC2_MCP_like
93 184 SUPERFAMILY SSF103190 Sensory domain-like
93 184 InterPro IPR029151 Periplasmic sensor-like domain superfamily
1 25 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
547 609 ProSiteProfiles PS50192 t-SNARE coiled-coil homology domain profile.
547 609 InterPro IPR000727 Target SNARE coiled-coil homology domain
299 351 Pfam PF00672 HAMP domain
299 351 InterPro IPR003660 HAMP domain
12 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
397 596 CDD cd11386 MCP_signal
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
301 355 ProSiteProfiles PS50885 HAMP domain profile.
281 304 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 177 Gene3D G3DSA:3.30.450.20 PAS domain
302 632 Gene3D G3DSA:1.10.287.950 -
370 631 SMART SM00283 MA_2
370 631 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
37 263 Pfam PF02743 Cache domain
37 263 InterPro IPR033479 Double Cache domain 1
414 597 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
414 597 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
30 280 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
501 524 Coils Coil Coil
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
60 179 CDD cd12913 PDC1_MCP_like
360 596 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
360 596 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5LTV
X-ray 2.31 Å A,B,C,D,E,F,G
39.9% 30-281
PDBe RCSB PDBj File
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AlphaFold PA4307
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.708
2 0.207

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.95 0.224

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
TAU
5AVF
Q9KL26 125.1 Da LogP -1.17 TPSA 80.4 ✓ Ro5 ✓ Clean C(CS(=O)(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.