Protein profile

PA4308

hypothetical protein

Genome: NC_002516.2

Gene: PA4308 Structure source: AlphaFold UniProt Q9HW92

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Amino acids 496

Annotations 1

Features 12

PDB binders 0

Druggability 0.784

Overview

Basic information about this protein and its source genome.

Accession: PA4308
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4308
Status: annotated
Amino acids: 496
Structure source: AlphaFold

GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.784

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
8	495	Pfam	PF05872	Helicase HerA-like C-terminal
8	495	InterPro	IPR033186	Helicase HerA-like C-terminal
206	385	Gene3D	G3DSA:3.40.50.300	-
206	385	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
7	386	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
7	386	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
25	331	SMART	SM00382	AAA_5
25	331	InterPro	IPR003593	AAA+ ATPase domain
4	144	Gene3D	G3DSA:3.40.50.300	-
4	144	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
25	485	PANTHER	PTHR30121	UNCHARACTERIZED PROTEIN YJGR-RELATED
427	447	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4308	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.784
2				0.422