Protein profile

PA4315

transcriptional regulator MvaT

Genome: NC_002516.2

Gene: PA4315 mvaT Structure source: AlphaFold UniProt Q9HW86
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Amino acids 124
Annotations 6
Features 3
PDB binders 0
Druggability 0.955

Overview

Basic information about this protein and its source genome.

Accession
PA4315
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4315 mvaT
Status
annotated
Amino acids
124
Structure source
AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:1900377 Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. GO:1900232 Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.955
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:1900377 Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process.
  • GO:1900232 Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

3 records
Show feature table
Start End DB Term Name
7 34 Coils Coil Coil
80 121 CDD cd16170 MvaT_DBD
80 121 InterPro IPR035616 MvaT, DNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4315
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.955