Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4341
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4341
Status: annotated
Amino acids: 256
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.861

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
10	70	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
10	70	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
3	255	PANTHER	PTHR30136	HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY
10	99	SMART	SM00346	iclrneu
10	99	InterPro	IPR005471	Transcription regulator IclR, N-terminal
83	256	Gene3D	G3DSA:3.30.450.40	-
83	256	InterPro	IPR029016	GAF-like domain superfamily
12	60	Pfam	PF09339	IclR helix-turn-helix domain
12	60	InterPro	IPR005471	Transcription regulator IclR, N-terminal
85	255	SUPERFAMILY	SSF55781	GAF domain-like
2	69	Gene3D	G3DSA:1.10.10.10	-
2	69	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
70	256	ProSiteProfiles	PS51078	IclR effector binding domain profile.
70	256	InterPro	IPR014757	Transcription regulator IclR, C-terminal
10	71	ProSiteProfiles	PS51077	IclR-type HTH domain profile.
10	71	InterPro	IPR005471	Transcription regulator IclR, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4341	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.861
1				0.857
4				0.255

PA4341