Protein profile

PA4350

hypothetical protein

Genome: NC_002516.2

Gene: olsB PA4350 Structure source: AlphaFold UniProt Q9HW51
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Amino acids 251
Annotations 3
Features 5
PDB binders 0
Druggability 0.692

Overview

Basic information about this protein and its source genome.

Accession
PA4350
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
olsB PA4350
Status
annotated
Amino acids
251
Structure source
AlphaFold
EC
2.3.2.30
GO
GO:0043810 Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids. GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.692
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTQTAITREPVAGRRLKAERLNGARALREAQALRYRVFSAEFDAKLEGAEDGLDRDDYDRHCAHIGVRDLDSGALVATTRLLDHRAAERLGRFYSEEEFHLSGLDALHGPVLEIGRTCVAPEYRNGATIAVLWGELAEVLNEGGYRYLMGCASIPMRDGGMQAKAVMQRLRERYLCTDYLQAEPKNPLPPLDVPENLTAELPPLLKAYMRLGAKICGEPCWDPDFQVADVFILLKRDELCPRYARHFKAAV

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0043810 Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids.
  • GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
17 181 Gene3D G3DSA:3.40.630.30 -
23 223 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
23 223 InterPro IPR016181 Acyl-CoA N-acyltransferase
33 133 Pfam PF13444 Acetyltransferase (GNAT) domain
22 249 PANTHER PTHR37323 GCN5-RELATED N-ACETYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4350
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.692