Protein profile

PA4351

acyltransferase

Genome: NC_002516.2

Gene: PA4351 olsA Structure source: AlphaFold UniProt Q9HW50
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Amino acids 258
Annotations 7
Features 14
PDB binders 1
Druggability 0.963

Overview

Basic information about this protein and its source genome.

Accession
PA4351
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4351 olsA
Status
annotated
Amino acids
258
Structure source
AlphaFold
EC
2.3.1.270
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0003841 Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0016036 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. GO:0046467 OBSOLETE. The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. GO:0006654 The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
33.613
Human E-value
2.98e-07
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.963
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0003841 Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
  • GO:0016036 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
  • GO:0046467 OBSOLETE. The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane.
  • GO:0006654 The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 12 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
46 227 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
30 242 PANTHER PTHR10434 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE
31 258 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
72 183 SMART SM00563 plsc_2
72 183 InterPro IPR002123 Phospholipid/glycerol acyltransferase
50 242 CDD cd07989 LPLAT_AGPAT-like
61 181 Pfam PF01553 Acyltransferase
61 181 InterPro IPR002123 Phospholipid/glycerol acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4351
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.963

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

47 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
DD9
5KYM
Q9X219 128.3 Da LogP 3.76 TPSA 0.0 ✓ Ro5 ✓ Clean CCCCCCCCC

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.