Protein profile

PA4353

hypothetical protein

Genome: NC_002516.2

Gene: PA4353 Structure source: AlphaFold UniProt Q9HW48
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Amino acids 190
Annotations 2
Features 6
PDB binders 0
Druggability 0.737

Overview

Basic information about this protein and its source genome.

Accession
PA4353
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4353
Status
annotated
Amino acids
190
Structure source
AlphaFold
GO
GO:0008770 Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein. GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MNYLAHLHLGGPQPAQLLGSLYGDFVKGRLQGQWPDEIERAIQLHRRIDAFTDSHPLVHAAKRRFPLERRRFAGVLLDVFFDHCLARDWNDYADEPLPQFVERVYGTLRTASPLPERLARIAPRMAAQDWLGSYREFAVLREVLGGMSRRLSRPHLLDGSWEELAQRYDDLSADFRAFYPQLQAFALSQR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008770 Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.
  • GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
1 190 PIRSF PIRSF011489 UCP011489
1 190 InterPro IPR007431 Acyl carrier protein phosphodiesterase
81 184 Pfam PF04336 Acyl carrier protein phosphodiesterase
81 184 InterPro IPR007431 Acyl carrier protein phosphodiesterase
1 188 PANTHER PTHR38764 ACYL CARRIER PROTEIN PHOSPHODIESTERASE
1 188 InterPro IPR007431 Acyl carrier protein phosphodiesterase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4353
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.737
5 0.41
6 0.305