Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4354
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4354
Status: annotated
Amino acids: 100
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:1900231 Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.867

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:1900231 Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
9	98	CDD	cd00090	HTH_ARSR
9	98	InterPro	IPR011991	ArsR-like helix-turn-helix domain
6	91	NCBIfam	NF033788	metalloregulator ArsR/SmtB family transcription factor
1	100	ProSiteProfiles	PS50987	ArsR-type HTH domain profile.
1	100	InterPro	IPR001845	HTH ArsR-type DNA-binding domain
7	98	SMART	SM00418	arsrmega2
7	98	InterPro	IPR001845	HTH ArsR-type DNA-binding domain
6	78	Pfam	PF12840	Helix-turn-helix domain
3	99	Gene3D	G3DSA:1.10.10.10	-
3	99	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
3	97	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
3	97	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
6	98	PANTHER	PTHR33154	TRANSCRIPTIONAL REGULATOR, ARSR FAMILY

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4354	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.867
2				0.291

PA4354