Protein profile

PA4363

chromosome replication initiation inhibitor protein

Genome: NC_002516.2

Gene: iciA argP PA4363 Structure source: AlphaFold UniProt Q9HW38
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Amino acids 300
Annotations 3
Features 29
PDB binders 1
Druggability 0.889

Overview

Basic information about this protein and its source genome.

Accession
PA4363
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
iciA argP PA4363
Status
annotated
Amino acids
300
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.889
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
86 291 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
1 297 Hamap MF_00513 HTH-type transcriptional regulator ArgP [argP].
1 297 InterPro IPR023490 HTH-type transcriptional regulator ArgP, gammaproteobacteria
4 292 NCBIfam TIGR03298 ArgP/LysG family DNA-binding transcriptional regulator
4 292 InterPro IPR017685 HTH-type transcriptional regulator ArgP
8 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
79 298 Gene3D G3DSA:3.40.190.290 -
7 64 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
7 64 InterPro IPR000847 Transcription regulator HTH, LysR
28 300 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 78 Gene3D G3DSA:1.10.10.10 -
3 78 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
1 293 PANTHER PTHR30579 TRANSCRIPTIONAL REGULATOR
21 32 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
21 32 InterPro IPR000847 Transcription regulator HTH, LysR
32 42 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
32 42 InterPro IPR000847 Transcription regulator HTH, LysR
42 53 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
42 53 InterPro IPR000847 Transcription regulator HTH, LysR
3 78 FunFam G3DSA:1.10.10.10:FF:000061 HTH-type transcriptional regulator ArgP
4 60 ProSiteProfiles PS50931 LysR-type HTH domain profile.
4 60 InterPro IPR000847 Transcription regulator HTH, LysR
92 279 Pfam PF03466 LysR substrate binding domain
92 279 InterPro IPR005119 LysR, substrate-binding
17 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
3 112 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
3 112 InterPro IPR036390 Winged helix DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4363
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.889
2 0.748

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
P33
3FD3
A9CJQ0 326.4 Da LogP -0.93 TPSA 95.8 ✓ Ro5 ✓ Clean C(COCCOCCOCCOCCOCCOCCO)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.