Protein profile

PA4370

insulin-cleaving metalloproteinase outer membrane protein

Genome: NC_002516.2

Gene: icmP PA4370 Structure source: Experimental + AlphaFold UniProt Q9HW32
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Amino acids 446
Annotations 2
Features 14
PDB binders 0
Druggability 0.307

Overview

Basic information about this protein and its source genome.

Accession
PA4370
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
icmP PA4370
Status
annotated
Amino acids
446
Structure source
Experimental + AlphaFold
GO
GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.307
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
62 421 CDD cd14657 Imelysin_IrpA-like
6 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 446 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
1 29 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
67 423 Pfam PF09375 Imelysin
67 423 InterPro IPR018976 Imelysin-like domain
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 19 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 21 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
27 430 Gene3D G3DSA:1.20.1420.20 M75 peptidase, HXXE motif
27 430 InterPro IPR038352 Imelysin-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7XRX
X-ray 1.88 Å A,B,C
89.2% 49-446
PDBe RCSB PDBj File
Viewing
AlphaFold PA4370
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.307
2 0.27

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.84 0.416
2 7.06 0.366
3 4.17 0.17
4 1.76 0.032