Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4371
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4371
Status: annotated
Amino acids: 473
Structure source: AlphaFold

GO

GO:0004130 Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.554

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0004130 Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
25	473	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
10	19	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
330	473	SUPERFAMILY	SSF46626	Cytochrome c
330	473	InterPro	IPR036909	Cytochrome c-like domain superfamily
20	24	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	24	Phobius	SIGNAL_PEPTIDE	Signal peptide region
322	473	Gene3D	G3DSA:1.10.760.10	-
322	473	InterPro	IPR036909	Cytochrome c-like domain superfamily
10	473	PANTHER	PTHR30600	CYTOCHROME C PEROXIDASE-RELATED
3	473	PIRSF	PIRSF028099	Thiol_oxidored
3	473	InterPro	IPR010538	Di-haem oxidoreductase, putative peroxidase
1	24	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	24	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
36	473	Pfam	PF06537	Di-haem oxidoreductase, putative peroxidase
36	473	InterPro	IPR010538	Di-haem oxidoreductase, putative peroxidase
341	473	ProSiteProfiles	PS51007	Cytochrome c family profile.
341	473	InterPro	IPR009056	Cytochrome c-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4371	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.554
1				0.259

PA4371