Protein profile

PA4372

hypothetical protein

Genome: NC_002516.2

Gene: PA4372 Structure source: AlphaFold UniProt Q9HW30

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Amino acids 354

Annotations 1

Features 14

PDB binders 0

Druggability 0.878

Overview

Basic information about this protein and its source genome.

Accession: PA4372
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4372
Status: annotated
Amino acids: 354
Structure source: AlphaFold

GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.878

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
6	15	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
16	20	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	20	SignalP_EUK	SignalP-noTM	SignalP-noTM
1	18	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
20	354	Gene3D	G3DSA:1.20.1420.20	M75 peptidase, HXXE motif
20	354	InterPro	IPR038352	Imelysin-like domain superfamily
36	332	Pfam	PF09375	Imelysin
36	332	InterPro	IPR018976	Imelysin-like domain
1	5	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
21	354	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29	354	CDD	cd14659	Imelysin-like_IPPA
29	354	InterPro	IPR034984	IPPA , imelysin-like domain
1	25	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	20	Phobius	SIGNAL_PEPTIDE	Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4372	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.878