Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4374
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4374
Status: annotated
Amino acids: 376
Structure source: AlphaFold

GO

GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.662

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MLLRRMLIMLAAVIAVVAILAGYKVYSIRQQIALFSAPKPPISVTASLAEKRPWQSRLPAIGSLKAFQGVTLTAEVSGTVRDVLFLSGDQVKLDQPLIQLESDVEEATLRTAEADLGLARAEYQRGRELIGSKAISKSEFDRLAAQWAKTSATVAELKAALAKKRVLAPFAGTIGIRQVDVGDYVSPGTPIATLQDLSTLLLDFHLPEQDFPLLSRGQLVKVRVAAYPAQVFDAEIAAINPKVDNETRNLQVRAALENPDGKLLPGMFANLEVMLPGEEQRVVVPETAITFTLYGDSIYVVGQKKDEQGQVSKDDKGQPQQVVERRFVRIGERREGLAVVLEGLEGGEQVVTSGQLKLDNGAAVAIVAERDLQQEH

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
22	27	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	27	Phobius	SIGNAL_PEPTIDE	Signal peptide region
71	269	Pfam	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion
71	269	InterPro	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain
7	29	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
191	274	Gene3D	G3DSA:2.40.30.170	-
1	10	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
10	21	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
28	376	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
276	376	Gene3D	G3DSA:2.40.420.20	-
188	275	FunFam	G3DSA:2.40.30.170:FF:000010	Efflux RND transporter periplasmic adaptor subunit
70	190	Gene3D	G3DSA:2.40.50.100	-
44	366	NCBIfam	TIGR01730	efflux RND transporter periplasmic adaptor subunit
44	366	InterPro	IPR006143	RND efflux pump, membrane fusion protein
60	273	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
4	369	PANTHER	PTHR30469	MULTIDRUG RESISTANCE PROTEIN MDTA
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
100	165	FunFam	G3DSA:1.10.287.470:FF:000026	Efflux RND transporter periplasmic adaptor subunit
100	165	Gene3D	G3DSA:1.10.287.470	Helix hairpin bin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4374	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
7				0.662
9				0.554
5				0.207

PA4374