Protein profile

PA4376

nicotinate phosphoribosyltransferase

Genome: NC_002516.2

Gene: pncB2 PA4376 Structure source: Experimental + AlphaFold UniProt Q9HW26
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Amino acids 398
Annotations 5
Features 20
PDB binders 0
Druggability 0.902

Overview

Basic information about this protein and its source genome.

Accession
PA4376
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pncB2 PA4376
Status
annotated
Amino acids
398
Structure source
Experimental + AlphaFold
EC
6.3.4.21
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004516 Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. GO:0034355 The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis. GO:0009435 The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.902
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0004516 Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate.
  • GO:0034355 The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis.
  • GO:0009435 The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
171 397 Pfam PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family
171 397 InterPro IPR041525 Nicotinate/nicotinamide phosphoribosyltransferase
12 380 CDD cd01401 PncB_like
12 380 InterPro IPR006406 Nicotinate phosphoribosyltransferase
3 398 FunFam G3DSA:3.20.140.10:FF:000001 Nicotinate phosphoribosyltransferase
8 389 PANTHER PTHR11098 NICOTINATE PHOSPHORIBOSYLTRANSFERASE
8 389 InterPro IPR007229 Nicotinate phosphoribosyltransferase family
142 162 Coils Coil Coil
15 132 Pfam PF17767 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain
15 132 InterPro IPR040727 Nicotinate phosphoribosyltransferase, N-terminal domain
1 385 PIRSF PIRSF000484 NAPRT
1 385 InterPro IPR007229 Nicotinate phosphoribosyltransferase family
6 140 SUPERFAMILY SSF54675 Nicotinate/Quinolinate PRTase N-terminal domain-like
122 396 SUPERFAMILY SSF51690 Nicotinate/Quinolinate PRTase C-terminal domain-like
122 396 InterPro IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal
4 398 Gene3D G3DSA:3.20.140.10 nicotinate phosphoribosyltransferase
10 397 NCBIfam TIGR01514 nicotinate phosphoribosyltransferase
10 397 InterPro IPR006406 Nicotinate phosphoribosyltransferase
7 398 Hamap MF_00570 Nicotinate phosphoribosyltransferase [pncB].
7 398 InterPro IPR006406 Nicotinate phosphoribosyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1YIR
X-ray 2.10 Å A,B,C,D
99.7% 2-398
PDBe RCSB PDBj File
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AlphaFold PA4376
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.413

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.86 0.923
2 11.23 0.601
3 1.9 0.038