Protein profile

PA4386

co-chaperonin GroES

Genome: NC_002516.2

Gene: PA4386 mopB groS groES Structure source: AlphaFold UniProt P30720
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Amino acids 97
Annotations 7
Features 23
PDB binders 0
Druggability 0.912

Overview

Basic information about this protein and its source genome.

Accession
PA4386
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4386 mopB groS groES
Status
annotated
Amino acids
97
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872 Binding to a metal ion. GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process. GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0051082 Binding to an unfolded protein.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
51.111
Human E-value
3.54e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.912
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046872 Binding to a metal ion.
  • GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process.
  • GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
3 27 ProSitePatterns PS00681 Chaperonins cpn10 signature.
3 27 InterPro IPR018369 Chaperonin GroES, conserved site
1 97 Gene3D G3DSA:2.30.33.40 GroES chaperonin
1 97 InterPro IPR037124 GroES chaperonin superfamily
2 95 SMART SM00883 Cpn10_2
2 95 InterPro IPR020818 GroES chaperonin family
2 94 Pfam PF00166 Chaperonin 10 Kd subunit
2 94 InterPro IPR020818 GroES chaperonin family
1 96 SUPERFAMILY SSF50129 GroES-like
1 96 InterPro IPR011032 GroES-like superfamily
2 96 Hamap MF_00580 Co-chaperonin GroES [groES].
2 96 InterPro IPR020818 GroES chaperonin family
2 95 CDD cd00320 cpn10
2 94 PANTHER PTHR10772 10 KDA HEAT SHOCK PROTEIN
1 97 FunFam G3DSA:2.30.33.40:FF:000001 10 kDa chaperonin
25 46 PRINTS PR00297 10kDa chaperonin signature
25 46 InterPro IPR020818 GroES chaperonin family
3 18 PRINTS PR00297 10kDa chaperonin signature
3 18 InterPro IPR020818 GroES chaperonin family
60 72 PRINTS PR00297 10kDa chaperonin signature
60 72 InterPro IPR020818 GroES chaperonin family
82 95 PRINTS PR00297 10kDa chaperonin signature
82 95 InterPro IPR020818 GroES chaperonin family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4386
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.912

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

5 records

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Show only:
Ligand UniProt (homolog) pchembl MW · LogP · TPSA Lipinski PAINS SMILES
DWT P61604 7.12 503.5 Da LogP 5.75 TPSA 97.6 2 viol. ✓ Clean Cc1ccc(cc1Nc2c3cn(nc3nc(n2)c4cccnc4)C)C(=O)Nc5c…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.