Protein profile

PA4402

bifunctional ornithine acetyltransferase/N-acetylglutamate synthase

Genome: NC_002516.2

Gene: PA4402 argJ Structure source: AlphaFold UniProt Q9HW04
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Amino acids 405
Annotations 5
Features 15
PDB binders 2
Druggability 0.343

Overview

Basic information about this protein and its source genome.

Accession
PA4402
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4402 argJ
Status
annotated
Amino acids
405
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004042 Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+. GO:0004358 Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. GO:0006526 The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0006592 The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.343
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004042 Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+.
  • GO:0004358 Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.
  • GO:0006526 The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
  • GO:0006592 The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
14 405 CDD cd02152 OAT
14 405 InterPro IPR002813 Arginine biosynthesis protein ArgJ
14 405 PANTHER PTHR23100 ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ
8 275 FunFam G3DSA:3.60.70.12:FF:000001 Arginine biosynthesis bifunctional protein ArgJ, chloroplastic
276 405 FunFam G3DSA:3.10.20.340:FF:000001 Arginine biosynthesis bifunctional protein ArgJ, chloroplastic
14 405 NCBIfam TIGR00120 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase
1 405 Hamap MF_01106 Arginine biosynthesis bifunctional protein ArgJ [argJ].
1 405 InterPro IPR002813 Arginine biosynthesis protein ArgJ
276 405 Gene3D G3DSA:3.10.20.340 -
276 405 InterPro IPR042195 ArgJ beta chain, C-terminal domain
9 275 Gene3D G3DSA:3.60.70.12 -
21 405 Pfam PF01960 ArgJ family
21 405 InterPro IPR002813 Arginine biosynthesis protein ArgJ
14 402 SUPERFAMILY SSF56266 DmpA/ArgJ-like
14 402 InterPro IPR016117 ArgJ-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4402
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.343
3 0.22

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
BEZ
3IT4
P9WPZ3 122.1 Da LogP 1.38 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc(cc1)C(=O)O
ORN
3IT6
P9WPZ3 132.2 Da LogP -0.86 TPSA 89.3 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)CN

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.