Protein profile

PA4421

cell division protein MraZ

Genome: NC_002516.2

Gene: mraZ PA4421 Structure source: AlphaFold UniProt Q9HVZ4
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Amino acids 151
Annotations 7
Features 23
PDB binders 0
Druggability 0.213

Overview

Basic information about this protein and its source genome.

Accession
PA4421
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
mraZ PA4421
Status
annotated
Amino acids
151
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009295 The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:2000143 Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.213
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009295 The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:2000143 Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
1 138 Gene3D G3DSA:3.40.1550.20 Transcriptional regulator MraZ domain
1 138 InterPro IPR038619 MraZ superfamily
1 75 Pfam PF02381 MraZ protein, putative antitoxin-like
1 75 InterPro IPR020603 MraZ domain
78 132 Pfam PF02381 MraZ protein, putative antitoxin-like
78 132 InterPro IPR020603 MraZ domain
1 151 Hamap MF_01008 Transcriptional regulator MraZ [mraZ].
1 151 InterPro IPR003444 Transcriptional regulator MraZ
5 52 ProSiteProfiles PS51740 SpoVT-AbrB domain profile.
5 52 InterPro IPR007159 SpoVT-AbrB domain
71 132 CDD cd16321 MraZ_C
71 132 InterPro IPR035644 MraZ, C-terminal
3 64 CDD cd16320 MraZ_N
3 64 InterPro IPR035642 MraZ, N-terminal
81 124 ProSiteProfiles PS51740 SpoVT-AbrB domain profile.
81 124 InterPro IPR007159 SpoVT-AbrB domain
1 149 PANTHER PTHR34701 TRANSCRIPTIONAL REGULATOR MRAZ
1 149 InterPro IPR003444 Transcriptional regulator MraZ
1 136 NCBIfam TIGR00242 division/cell wall cluster transcriptional repressor MraZ
1 136 InterPro IPR003444 Transcriptional regulator MraZ
1 136 SUPERFAMILY SSF89447 AbrB/MazE/MraZ-like
1 136 InterPro IPR037914 SpoVT-AbrB domain superfamily
1 141 FunFam G3DSA:3.40.1550.20:FF:000001 Transcriptional regulator MraZ

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4421
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.213