Protein profile

PA4422

hypothetical protein

Genome: NC_002516.2

Gene: rsmI PA4422 Structure source: AlphaFold UniProt Q9HVZ3
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Amino acids 282
Annotations 4
Features 22
PDB binders 0
Druggability 0.64

Overview

Basic information about this protein and its source genome.

Accession
PA4422
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
rsmI PA4422
Status
annotated
Amino acids
282
Structure source
AlphaFold
EC
2.1.1.198
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0070677 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.64
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSAGTLFVVATPIGNLDDISPRALRVLREVALVAAEDTRHSIRLFQHFGIETPLAACHEHNEREEGGRFISRLQGGEDVALISDAGTPLISDPGFHLVRQAQALGIRVVPVPGSCALIAALSAAGLPSDRFIFEGFLPAKAAGRRSRLQAVQEEPRTLIFYEAPHRLLESLADMRDVFGGERRAVLARELSKTFETIRSLPLAELHDWVASDSNQQRGECVVLVAGWQAPEGEESIGAEALRVLDLLLAELPLKKAAALAAEITGVRKNLLYQQALQRQGKS

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0070677 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 112 Gene3D G3DSA:3.40.1010.10 -
1 112 InterPro IPR014777 Tetrapyrrole methylase, subdomain 1
2 280 PANTHER PTHR46111 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I
2 280 InterPro IPR008189 rRNA small subunit methyltransferase I
4 224 SUPERFAMILY SSF53790 Tetrapyrrole methylase
4 224 InterPro IPR035996 Tetrapyrrole methylase superfamily
83 94 ProSitePatterns PS01296 RsmI AdoMet-dependent methyltransferase protein family signature.
83 94 InterPro IPR018063 SAM-dependent methyltransferase RsmI, conserved site
1 112 FunFam G3DSA:3.40.1010.10:FF:000002 Ribosomal RNA small subunit methyltransferase I
7 225 CDD cd11648 RsmI
7 225 InterPro IPR008189 rRNA small subunit methyltransferase I
1 281 PIRSF PIRSF005917 MTase_YraL
1 281 InterPro IPR008189 rRNA small subunit methyltransferase I
5 226 Hamap MF_01877 Ribosomal RNA small subunit methyltransferase I [rsmI].
5 226 InterPro IPR008189 rRNA small subunit methyltransferase I
6 277 NCBIfam TIGR00096 16S rRNA (cytidine(1402)-2'-O)-methyltransferase
6 277 InterPro IPR008189 rRNA small subunit methyltransferase I
113 232 FunFam G3DSA:3.30.950.10:FF:000002 Ribosomal RNA small subunit methyltransferase I
113 231 Gene3D G3DSA:3.30.950.10 -
113 231 InterPro IPR014776 Tetrapyrrole methylase, subdomain 2
5 205 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases
5 205 InterPro IPR000878 Tetrapyrrole methylase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4422
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.64