Protein profile

PA4425

phosphoheptose isomerase

Genome: NC_002516.2

Gene: PA4425 gmhA Structure source: Experimental + AlphaFold UniProt Q9HVZ0
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Amino acids 197
Annotations 10
Features 12
PDB binders 1
Druggability 0.837

Overview

Basic information about this protein and its source genome.

Accession
PA4425
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4425 gmhA
Status
annotated
Amino acids
197
Structure source
Experimental + AlphaFold
EC
5.3.1.28
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990102 A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA. GO:0097367 Binding to a carbohydrate derivative. GO:0008968 Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. GO:0008270 Binding to a zinc ion (Zn). GO:2001061 The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.837
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:1990102 A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA.
  • GO:0097367 Binding to a carbohydrate derivative.
  • GO:0008968 Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:2001061 The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate.
  • GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.
  • GO:0032298 Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
2 192 Hamap MF_00067 Phosphoheptose isomerase [gmhA].
2 192 InterPro IPR004515 Phosphoheptose isomerase
36 197 ProSiteProfiles PS51464 SIS domain profile.
36 197 InterPro IPR001347 SIS domain
16 146 Pfam PF13580 SIS domain
16 146 InterPro IPR001347 SIS domain
3 194 PANTHER PTHR30390 SEDOHEPTULOSE 7-PHOSPHATE ISOMERASE / DNAA INITIATOR-ASSOCIATING FACTOR FOR REPLICATION INITIATION
11 190 CDD cd05006 SIS_GmhA
11 190 InterPro IPR035461 GmhA/DiaA
2 193 SUPERFAMILY SSF53697 SIS domain
2 193 InterPro IPR046348 SIS domain superfamily
1 197 Gene3D G3DSA:3.40.50.10490 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1X92
X-ray 2.30 Å A,B
100.0% 1-197
PDBe RCSB PDBj File
Viewing
PDB 3BJZ
X-ray 2.40 Å A,B,C,D
100.0% 1-197
PDBe RCSB PDBj File
Loaded
AlphaFold PA4425
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.837
3 0.389

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.71 0.03
2 1.39 0.017
3 0.97 0.005

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
I22
2I22
P63224 290.2 Da LogP -3.90 TPSA 185.0 1 viol. ✓ Clean C([C@H]([C@H]([C@H]([C@@H](C(=O)CO)O)O)O)O)OP(=…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.