Protein profile

PA4463

hypothetical protein

Genome: NC_002516.2

Gene: PA4463 Structure source: AlphaFold UniProt Q9HVV5
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Amino acids 102
Annotations 4
Features 12
PDB binders 0
Druggability 0.298

Overview

Basic information about this protein and its source genome.

Accession
PA4463
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4463
Status
annotated
Amino acids
102
Structure source
AlphaFold
GO
GO:0022627 The small subunit of a ribosome located in the cytosol. GO:0043024 Binding to a small ribosomal subunit. GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.298
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0022627 The small subunit of a ribosome located in the cytosol.
  • GO:0043024 Binding to a small ribosomal subunit.
  • GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.
  • GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 99 Gene3D G3DSA:3.30.160.100 -
1 99 InterPro IPR036567 Ribosome hibernation promotion factor-like
1 95 FunFam G3DSA:3.30.160.100:FF:000001 Ribosome hibernation promoting factor
1 95 SUPERFAMILY SSF69754 Ribosome binding protein Y (YfiA homologue)
1 95 InterPro IPR036567 Ribosome hibernation promotion factor-like
3 91 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein
3 91 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
2 91 CDD cd00552 RaiA
2 91 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
2 95 PANTHER PTHR33231 30S RIBOSOMAL PROTEIN
1 98 NCBIfam TIGR00741 ribosome-associated translation inhibitor RaiA
1 98 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4463
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.298