Overview
Basic information about this protein and its source genome.
- Accession
- PA4466
- Gene
- ptsH PA4466
- Status
- annotated
- Amino acids
- 90
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
2- GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
- GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 5 | 82 | CDD | cd00367 | PTS-HPr_like |
| 5 | 82 | InterPro | IPR000032 | Phosphocarrier protein HPr-like |
| 40 | 55 | ProSitePatterns | PS00589 | PTS HPR domain serine phosphorylation site signature. |
| 40 | 55 | InterPro | IPR002114 | Phosphotransferase system, HPr serine phosphorylation site |
| 13 | 29 | PRINTS | PR00107 | Phosphocarrier protein signature |
| 13 | 29 | InterPro | IPR000032 | Phosphocarrier protein HPr-like |
| 54 | 71 | PRINTS | PR00107 | Phosphocarrier protein signature |
| 54 | 71 | InterPro | IPR000032 | Phosphocarrier protein HPr-like |
| 39 | 54 | PRINTS | PR00107 | Phosphocarrier protein signature |
| 39 | 54 | InterPro | IPR000032 | Phosphocarrier protein HPr-like |
| 13 | 20 | ProSitePatterns | PS00369 | PTS HPR domain histidine phosphorylation site signature. |
| 13 | 20 | InterPro | IPR001020 | Phosphotransferase system, HPr histidine phosphorylation site |
| 1 | 83 | NCBIfam | TIGR01003 | HPr family phosphocarrier protein |
| 1 | 83 | InterPro | IPR000032 | Phosphocarrier protein HPr-like |
| 4 | 88 | PANTHER | PTHR33705 | PHOSPHOCARRIER PROTEIN HPR |
| 1 | 89 | Gene3D | G3DSA:3.30.1340.10 | - |
| 1 | 89 | InterPro | IPR035895 | HPr-like superfamily |
| 5 | 83 | Pfam | PF00381 | PTS HPr component phosphorylation site |
| 5 | 83 | InterPro | IPR000032 | Phosphocarrier protein HPr-like |
| 1 | 88 | SUPERFAMILY | SSF55594 | HPr-like |
| 1 | 88 | InterPro | IPR035895 | HPr-like superfamily |
| 1 | 89 | ProSiteProfiles | PS51350 | PTS HPR domain profile. |
| 1 | 89 | InterPro | IPR000032 | Phosphocarrier protein HPr-like |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA4466
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.48 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| PO3 | P0AA04 | 79.0 Da LogP -1.64 TPSA 63.2 | ✓ Ro5 | ✓ Clean |
[O-][P-](=O)[O-]
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
No virtual-screening candidates for this protein.
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.