Protein profile
PA4468
superoxide dismutase
Genome: NC_002516.2
Overview
Basic information about this protein and its source genome.
- Accession
- PA4468
- Gene
- sodM
- Status
- annotated
- Amino acids
- 203
- Structure source
- ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 66.667
- Human E-value
- 7.27e-13
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Periplasmic
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
3- GO:0004784 Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2.
- GO:0046872 Binding to a metal ion.
- GO:0006801 The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 3 | 89 | Pfam | PF00081 | Iron/manganese superoxide dismutases, alpha-hairpin domain |
| 3 | 89 | InterPro | IPR019831 | Manganese/iron superoxide dismutase, N-terminal |
| 6 | 17 | PRINTS | PR01703 | Manganese superoxide dismutase signature |
| 6 | 17 | InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| 72 | 85 | PRINTS | PR01703 | Manganese superoxide dismutase signature |
| 72 | 85 | InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| 27 | 40 | PRINTS | PR01703 | Manganese superoxide dismutase signature |
| 27 | 40 | InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| 162 | 174 | PRINTS | PR01703 | Manganese superoxide dismutase signature |
| 162 | 174 | InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| 125 | 133 | PRINTS | PR01703 | Manganese superoxide dismutase signature |
| 125 | 133 | InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| 20 | 87 | Gene3D | G3DSA:1.10.287.990 | Fe,Mn superoxide dismutase (SOD) domain |
| 20 | 87 | InterPro | IPR036324 | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
| 2 | 201 | PANTHER | PTHR43595 | 37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL |
| 88 | 201 | SUPERFAMILY | SSF54719 | Fe,Mn superoxide dismutase (SOD), C-terminal domain |
| 88 | 201 | InterPro | IPR036314 | Manganese/iron superoxide dismutase, C-terminal domain superfamily |
| 20 | 89 | FunFam | G3DSA:1.10.287.990:FF:000001 | Superoxide dismutase |
| 1 | 90 | SUPERFAMILY | SSF46609 | Fe,Mn superoxide dismutase (SOD), N-terminal domain |
| 1 | 90 | InterPro | IPR036324 | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
| 88 | 203 | Gene3D | G3DSA:3.55.40.20 | - |
| 88 | 203 | InterPro | IPR036314 | Manganese/iron superoxide dismutase, C-terminal domain superfamily |
| 1 | 203 | PIRSF | PIRSF000349 | MnSOD_FeSOD |
| 1 | 203 | InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| 96 | 197 | Pfam | PF02777 | Iron/manganese superoxide dismutases, C-terminal domain |
| 96 | 197 | InterPro | IPR019832 | Manganese/iron superoxide dismutase, C-terminal |
| 89 | 201 | FunFam | G3DSA:3.55.40.20:FF:000001 | Superoxide dismutase |
| 164 | 171 | ProSitePatterns | PS00088 | Manganese and iron superoxide dismutases signature. |
| 164 | 171 | InterPro | IPR019833 | Manganese/iron superoxide dismutase, binding site |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
No pockets are loaded yet for the displayed ColabFold model PA4468 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
ColabFold
PA4468
|
ColabFold | — | — | full sequence | — | Viewing |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| AZI | P00448 | 42.0 Da LogP 0.87 TPSA 58.7 | ✓ Ro5 | Alert |
[N-]=[N+]=[N-]
|
|
| MH2 | P00448 | 71.9 Da LogP -0.56 TPSA 20.2 | ✓ Ro5 | ✓ Clean |
O[Mn+2]
|
|
| O | P0AGD3 | 18.0 Da LogP -0.82 TPSA 31.5 | ✓ Ro5 | ✓ Clean |
O
|
|
| PEO | P00448 | 34.0 Da LogP 0.02 TPSA 40.5 | ✓ Ro5 | ✓ Clean |
OO
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
No virtual-screening candidates for this protein.
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.