Protein profile

PA4477

cytoplasmic axial filament protein

Genome: NC_002516.2

Gene: cafA PA4477 Structure source: AlphaFold UniProt Q9HVU4
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Amino acids 485
Annotations 12
Features 20
PDB binders 1
Druggability 0.498

Overview

Basic information about this protein and its source genome.

Accession
PA4477
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
cafA PA4477
Status
annotated
Amino acids
485
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion. GO:0004540 Catalysis of the cleavage of phosphodiester bonds in chains of RNA. GO:0019843 Binding to a ribosomal RNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.498
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

12 GO

Gene Ontology (GO)

12
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.
  • GO:0004540 Catalysis of the cleavage of phosphodiester bonds in chains of RNA.
  • GO:0019843 Binding to a ribosomal RNA.
  • GO:0000049 Binding to a transfer RNA.
  • GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0006396 Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
  • GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
38 100 Pfam PF00575 S1 RNA binding domain
38 100 InterPro IPR003029 S1 domain
31 118 Gene3D G3DSA:2.40.50.140 -
31 118 InterPro IPR012340 Nucleic acid-binding, OB-fold
39 113 ProSiteProfiles PS50126 S1 domain profile.
39 113 InterPro IPR003029 S1 domain
14 422 NCBIfam TIGR00757 Rne/Rng family ribonuclease
14 422 InterPro IPR004659 Ribonuclease E/G
398 485 Gene3D G3DSA:3.40.1260.20 Ribonuclease E, catalytic domain
37 113 SMART SM00316 S1_6
37 113 InterPro IPR022967 RNA-binding domain, S1
3 483 PANTHER PTHR30001 RIBONUCLEASE
3 483 InterPro IPR004659 Ribonuclease E/G
34 119 CDD cd04453 S1_RNase_E
347 367 Coils Coil Coil
115 389 Pfam PF10150 Ribonuclease E/G family
115 389 InterPro IPR019307 RNA-binding protein AU-1/Ribonuclease E/G
399 485 FunFam G3DSA:3.40.1260.20:FF:000001 Ribonuclease G Rng
39 118 SUPERFAMILY SSF50249 Nucleic acid-binding proteins
39 118 InterPro IPR012340 Nucleic acid-binding, OB-fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4477
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.498

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
U
6G63
P21513 324.2 Da LogP -2.73 TPSA 171.3 ✓ Ro5 ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.