Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4480
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4480 mreC
Status: annotated
Amino acids: 330
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0008360 Any process that modulates the surface configuration of a cell.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.94

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0046872 Binding to a metal ion.
GO:0008360 Any process that modulates the surface configuration of a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records

Show feature table

Start	End	DB	Term	Name
1	14	Phobius	SIGNAL_PEPTIDE	Signal peptide region
262	276	MobiDBLite	mobidb-lite	consensus disorder prediction
168	240	FunFam	G3DSA:2.40.10.350:FF:000002	Cell shape-determining protein MreC
11	14	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
104	171	FunFam	G3DSA:2.40.10.340:FF:000002	Rod shape-determining protein MreC
4	261	NCBIfam	TIGR00219	rod shape-determining protein MreC
4	261	InterPro	IPR007221	Rod shape-determining protein MreC
96	167	Gene3D	G3DSA:2.40.10.340	-
96	167	InterPro	IPR042177	Cell/Rod shape-determining protein MreC, domain 1
15	330	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	268	PIRSF	PIRSF038471	MreC
1	268	InterPro	IPR007221	Rod shape-determining protein MreC
1	1	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
261	330	MobiDBLite	mobidb-lite	consensus disorder prediction
2	10	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
108	253	Pfam	PF04085	rod shape-determining protein MreC
108	253	InterPro	IPR007221	Rod shape-determining protein MreC
168	240	Gene3D	G3DSA:2.40.10.350	-
168	240	InterPro	IPR042175	Cell/Rod shape-determining protein MreC, domain 2
2	273	PANTHER	PTHR34138	CELL SHAPE-DETERMINING PROTEIN MREC
2	273	InterPro	IPR007221	Rod shape-determining protein MreC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
PDB 6ZM0	X-ray	1.47 Å	AAA	49.1% 97-258	PDBe RCSB PDBj File	Metadata only
AlphaFold PA4480	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.601
6				0.491
1				0.253

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

No PDB ligands found through similar proteins.

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Ligand	UniProt (homolog)	pchembl	MW · LogP · TPSA	Lipinski	PAINS	SMILES
FOM	P16926	—	183.1 Da LogP -0.60 TPSA 98.1	✓ Ro5	✓ Clean	`C(CN(C=O)O)CP(=O)(O)O`

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA4480