Protein profile

PA4489

hypothetical protein

Genome: NC_002516.2

Gene: PA4489 Structure source: AlphaFold UniProt Q9HVT2
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Amino acids 1516
Annotations 1
Features 25
PDB binders 0
Druggability 0.705

Overview

Basic information about this protein and its source genome.

Accession
PA4489
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4489
Status
annotated
Amino acids
1516
Structure source
AlphaFold
GO
GO:0004866 Binds to and stops, prevents or reduces the activity of an endopeptidase.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.531
Human E-value
5.83e-06
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.705
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSNLRRFSRSLAVAALVLLPFAAVQAEDTVEPSGYTPMAGESFFLLADSSFATDEEARVRLEAPGRDYRRYRMEPYGGVDVRLYRIEQPLEFLKRQKNLHRVLAEGQFKGEGLSNTLAYLWDNWYRKSRRVMQRAFSYESRQQVTEAVPELKMGNAMTAPTPYDAQPQYAPIPGLPLVSQFRYPLWDAKPIEPPQDVKLAGSSSEFINVVPGNVYIPLGKLKPGLYLVEALVGKYRATTVVFVSNSVAVSKVAGDELLVWTARKHEGTPVPDTKVLWTDGLGVMSSGNTDADGLLRLKHASPERSYVIGEDREGGVFVSENFYYDSEIYDTKIYAFTDRPLYRPGDWVSLKMVGREFKDARQSQAAASAPVRLSVIDASGTVLQSLDLRFDAKSGANGRFQLPENAVAGGYELRFDYRGQTYSSAFRVAEYIKPHFEVALDLAKPDFKTAEPVKGEIVLLYPDGKPVANARLQLSLRAQQLSMVDNELQYLGQFPVELSSTELTTDGKGRAAIELPPAEKPSRYMLTIFASDGAAYRVKTSKEILIERGAARYRLSAPQRFSAAGEKVEFSYASEQPTPLKPSSYQWIRLEDRATDSGPVADGRFALTFERPGTYSVELRDDKGQLLGATGHSVSGEGVKSVPGTVEVVFDKPEYRTGEEASALITFPEPVEDALLSLERDKVEATALLSKGADWLRLEKLNPTQYRVWIPVREEFSPNLTFSVLYTKGGDYSFQNAGIKVGMPQVEIDIATDKERYEPGETVTVTLATRFAGKPVSSHLTVSVVDEMVYALQAEIAPGIDQFFYHPRRNNVRTSASLAFISYDVALPGSTSAPGRANRSERGVKVLERPRREDVDTAAWQPELVTDAQGKASFSFRMPDSLTRWRITARAIDDNGQVGQKKQFLRSEKPLYLKWSGPTRFRQGDQPDLGLFVFNQGEQPVKAELLSGPPGSQRSQTLELAKGVNYIPLAQQPLSDGDWSAELRQDGQVRDRLAVRFNLLADGWQVEQMQNLSLAAASNPLQLPADARDVRLRLADGPAAAYLGNLDDLLEYPYGGVEQTASQLLPLSIAYPALAGGEPRIRDRLRLIMQNSRLRLVQMAGPDAWFAWWGGDVDGDAFLTAYAYYADWYASRALEIQLPAEHWQRILEPYAKQATQTPLLQRALILAFARDMQLPVNTLLGGLLNDLANAGEGQARAEPLEADDGLVLGDPDSAVGLAAARVLAVDLARQLRVAVPAPLAAQAETATQRLREAGLPFTDALLASRSAVDGQQASALLQRLAPAQSTLERALALTWLQGALAQAPQGKLPQPPKDWQAQRGASGETYWQWRGRGIPSWVDLDEAPARPLPVALSYRSAQAPSGQLPVQISRRLLRLVPGEGAFEFKVEEVGDKPLSSDELYLDEVTLNVPEDTALRYGMLELPLPPGADVERTTWGIKISGLAGDEATTLERARNEPGELFYGVPVDSLSGEQRFRHLVRFSQKGSFNLPPARYLRLYAPEQQALEAKPALAKVKVE

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004866 Binds to and stops, prevents or reduces the activity of an endopeptidase.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
1 26 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
743 909 Gene3D G3DSA:2.20.130.20 -
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
10 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
1045 1074 SMART SM01419 Thiol_ester_cl_2
1045 1074 InterPro IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
1043 1147 SUPERFAMILY SSF48239 Terpenoid cyclases/Protein prenyltransferases
1043 1147 InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
27 1516 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
702 1124 PANTHER PTHR11412 MACROGLOBULIN / COMPLEMENT
22 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1043 1336 Gene3D G3DSA:1.50.10.20 -
646 792 SMART SM01359 A2M_N_2_2
646 792 InterPro IPR011625 Alpha-2-macroglobulin, bait region domain
857 947 SMART SM01360 A2M_2
857 947 InterPro IPR001599 Alpha-2-macroglobulin
332 432 Gene3D G3DSA:2.60.40.1930 -
333 428 Pfam PF01835 MG2 domain
333 428 InterPro IPR002890 Macroglobulin domain
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
857 944 Pfam PF00207 Alpha-2-macroglobulin family
857 944 InterPro IPR001599 Alpha-2-macroglobulin
647 792 Pfam PF07703 Alpha-2-macroglobulin bait region domain
647 792 InterPro IPR011625 Alpha-2-macroglobulin, bait region domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4489
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.543
5 0.283