Protein profile

PA4490

hypothetical protein

Genome: NC_002516.2

Gene: PA4490 Structure source: Experimental + AlphaFold UniProt Q9HVT1
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Amino acids 212
Annotations 0
Features 10
PDB binders 0
Druggability 0.789

Overview

Basic information about this protein and its source genome.

Accession
PA4490
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4490
Status
annotated
Amino acids
212
Structure source
Experimental + AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.789
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
22 212 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
40 187 Gene3D G3DSA:3.90.1720.10 endopeptidase domain like (from Nostoc punctiforme)
21 210 Pfam PF06672 Protein of unknown function (DUF1175)
21 210 InterPro IPR009558 Protein of unknown function DUF1175
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7BK8
X-ray 1.74 Å A
100.0% 1-212
PDBe RCSB PDBj File
Viewing
AlphaFold PA4490
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.789

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.55 0.195