Protein profile

PA4495

hypothetical protein

Genome: NC_002516.2

Gene: PA4495 Structure source: AlphaFold UniProt Q9HVS6
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Amino acids 236
Annotations 1
Features 12
PDB binders 0
Druggability 0.529

Overview

Basic information about this protein and its source genome.

Accession
PA4495
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4495
Status
annotated
Amino acids
236
Structure source
AlphaFold
GO
GO:0006974 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.529
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006974 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
23 236 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
43 143 Gene3D G3DSA:3.30.70.2970 Protein of unknown function (DUF541), domain 2
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
38 226 Gene3D G3DSA:3.30.110.170 Protein of unknown function (DUF541), domain 1
31 226 Pfam PF04402 Protein of unknown function (DUF541)
31 226 InterPro IPR007497 Interleukin-1 receptor-associated kinase 1-binding protein 1/DUF541
5 234 PANTHER PTHR34387 SLR1258 PROTEIN
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4495
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.529