Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4503
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4503
Status: annotated
Amino acids: 336
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.843

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records

Show feature table

Start	End	DB	Term	Name
31	101	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
198	218	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
306	328	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
278	305	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
89	319	SUPERFAMILY	SSF161098	MetI-like
89	319	InterPro	IPR035906	MetI-like superfamily
102	123	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
329	336	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
104	123	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
96	325	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
96	325	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
9	30	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
256	277	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	335	PANTHER	PTHR43163	DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
9	31	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	8	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
99	316	CDD	cd06261	TM_PBP2
99	316	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
306	328	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
124	143	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
114	333	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
114	333	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
86	326	Gene3D	G3DSA:1.10.3720.10	-
86	326	InterPro	IPR035906	MetI-like superfamily
136	158	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
256	278	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	100	Pfam	PF19300	Binding-prot-dependent transport system membrane comp, N-term
1	100	InterPro	IPR045621	ABC transporter type 1, GsiC-like, N-terminal domain
144	162	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
198	220	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
219	255	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
163	197	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4503	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.843
3				0.718
1				0.412
9				0.286

PA4503