Protein target profile

PA4510

hypothetical protein

Genome: NC_002516.2

Gene: PA4510 3D evidence: AlphaFold DB model UniProt Q9HVR1

Export view

Length 225

Pocket druggability 0.695

EC / GO 0 / 2

Target summary

Target candidate with partial support; inspect missing evidence before prioritizing.

3 signals

Strengths

Risks / watch

No major risk signal surfaced in the loaded evidence.

Missing evidence

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.

How to read this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal TPW pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Overview

Basic information about this protein and its source genome.

Accession: PA4510
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4510
Status: annotated
Amino acids: 225
3D evidence: AlphaFold DB model

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: Hit
Essential (DEG): N
Localization: Cytoplasmic

Selected pocket evidence

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket 0.695

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MIRIEPAGAEALLLTLAEEPEVDLSVRLAELARRLREGLGEGVRDLVPGWTTLMLHYDPYRIASQILEERLGPLLAEWHAWRPAEDAGRLHEIPVWYAGEDLATVAVACGLTGEGVIELHSAAEYRVGAIGFAPGFAYLGGLDPRLVLPRRATPRARVPAGSLAIAEAQTAIYPQASPGGWHLLGRSPWRPFDPAATPPCPLALGDRVRFVAIGREAFLDLGGRE

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
2	222	PANTHER	PTHR34698	5-OXOPROLINASE SUBUNIT B
2	222	InterPro	IPR010016	5-oxoprolinase subunit B
2	202	SMART	SM00796	ahs1
2	202	InterPro	IPR003833	Carboxyltransferase domain, subdomain C and D
3	96	SUPERFAMILY	SSF160467	PH0987 N-terminal domain-like
3	202	Pfam	PF02682	Carboxyltransferase domain, subdomain C and D
3	202	InterPro	IPR003833	Carboxyltransferase domain, subdomain C and D
91	218	SUPERFAMILY	SSF50891	Cyclophilin-like
91	218	InterPro	IPR029000	Cyclophilin-like domain superfamily
9	211	NCBIfam	TIGR00370	5-oxoprolinase subunit PxpB
9	211	InterPro	IPR010016	5-oxoprolinase subunit B
91	225	Gene3D	G3DSA:2.40.100.10	-
91	225	InterPro	IPR029000	Cyclophilin-like domain superfamily
2	79	Gene3D	G3DSA:3.30.1360.40	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold DB PA4510	AlphaFold DB	—	—	full sequence	—	Viewing

Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.695

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Site 2 FPocket #3

0.244

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