Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4520
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4520
Status: annotated
Amino acids: 673
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.756

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MKTVLYPAIALMNRLSFGMKFGLISVLFFLPLLITSFYLVRDAYRQFSDTRIELQSLTLLGSGLQIRRGLESLNDLLQINAVIGQSGKAGDLEARIADVQKGLRGRLEALAPLSEDGAAVAEFEAQRDRLLNGLQAVEAEGSLQGKGARAEKLLGSAQVFIKLLIAQAGLSQDSQRQVRQLSELVGSITPEVTAAISKGRAIGAYSLGQGFLNSSSSARLDELLLEFEKLHGEYGLKLQESLAGSPQLLEEAAQASRETLKSLGQLFEDRVIVAETLDTPWTQFYDQVSVAMDKTYQLDDAVLGYLDTQLQKRLQQVRTQMLLLVAALAVVFAAILYLYGGFYVSTRATLKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNESVAKIHDLIERVSQTVGEVERQTLRVESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVDAAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVAHDIDQNIVEINQAGERTAEGASQTERASRELGAQVTQLKRLIGAFRV

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
345	673	FunFam	G3DSA:1.10.287.950:FF:000001	Methyl-accepting chemotaxis sensory transducer
350	391	Pfam	PF00672	HAMP domain
350	391	InterPro	IPR003660	HAMP domain
321	340	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
120	140	Coils	Coil	Coil
15	37	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
401	637	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
401	637	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
41	320	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	20	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
484	638	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
484	638	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
399	449	SMART	SM00304	HAMP_11
399	449	InterPro	IPR003660	HAMP domain
344	396	SMART	SM00304	HAMP_11
344	396	InterPro	IPR003660	HAMP domain
39	672	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
438	610	CDD	cd11386	MCP_signal
346	673	Gene3D	G3DSA:1.10.287.950	-
364	673	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
350	396	ProSiteProfiles	PS50885	HAMP domain profile.
350	396	InterPro	IPR003660	HAMP domain
341	673	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
350	391	CDD	cd06225	HAMP
21	40	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
411	672	SMART	SM00283	MA_2
411	672	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
322	344	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4520	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
8				0.756
5				0.506
2				0.327
22				0.304

PA4520