Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4525
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: fimA pilA PA4525
Status: annotated
Amino acids: 149
Structure source: AlphaFold

GO

GO:0009986 The external part of the cell wall and/or plasma membrane. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0044167 The lipid bilayer surrounding the host cell endoplasmic reticulum. GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.884

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

11 GO

Gene Ontology (GO)

11

GO:0009986 The external part of the cell wall and/or plasma membrane.
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0044167 The lipid bilayer surrounding the host cell endoplasmic reticulum.
GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.
GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
GO:0050848 Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
GO:0044011 A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.
GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
7	147	SUPERFAMILY	SSF54523	Pili subunits
7	147	InterPro	IPR045584	Pilin-like
7	29	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	149	FunFam	G3DSA:3.30.700.10:FF:000003	Type IV pilin
7	27	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
28	149	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35	147	Pfam	PF00114	Pilin (bacterial filament)
35	147	InterPro	IPR001082	Fimbrial protein pilin
7	149	Gene3D	G3DSA:3.30.700.10	Glycoprotein, Type 4 Pilin
1	6	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5	25	ProSitePatterns	PS00409	Prokaryotic N-terminal methylation site.
5	25	InterPro	IPR012902	Prokaryotic N-terminal methylation site
4	27	NCBIfam	TIGR02532	prepilin-type N-terminal cleavage/methylation domain
4	27	InterPro	IPR012902	Prokaryotic N-terminal methylation site
1	26	Pfam	PF07963	Prokaryotic N-terminal methylation motif
1	26	InterPro	IPR012902	Prokaryotic N-terminal methylation site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4525	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.884

PA4525