Amino acids
66
Annotations
3
Features
9
PDB binders
0
Overview
Basic information about this protein and its source genome.
- Accession
- PA4530
- Gene
- yacG PA4530
- Status
- annotated
- Amino acids
- 66
- Structure source
- AlphaFold
GO
GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
GO:0008270 Binding to a zinc ion (Zn).
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Unknown
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
3 GO
Gene Ontology (GO)
3- GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
- GO:0008270 Binding to a zinc ion (Zn).
- GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
Sequence Features
Domain/signature hits from InterPro and related databases.
9 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 55 | PANTHER | PTHR36150 | DNA GYRASE INHIBITOR YACG |
| 1 | 55 | InterPro | IPR005584 | DNA gyrase inhibitor YacG |
| 7 | 56 | Pfam | PF03884 | DNA gyrase inhibitor YacG |
| 7 | 56 | InterPro | IPR005584 | DNA gyrase inhibitor YacG |
| 2 | 55 | SUPERFAMILY | SSF57716 | Glucocorticoid receptor-like (DNA-binding domain) |
| 3 | 57 | Hamap | MF_00649 | DNA gyrase inhibitor YacG [yacG]. |
| 3 | 57 | InterPro | IPR005584 | DNA gyrase inhibitor YacG |
| 1 | 60 | Gene3D | G3DSA:3.30.50.10 | - |
| 1 | 60 | InterPro | IPR013088 | Zinc finger, NHR/GATA-type |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
No pockets are loaded yet for the displayed AlphaFold model PA4530 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA4530
|
AlphaFold | — | — | full sequence | — | Viewing |