Protein profile

PA4536

hypothetical protein

Genome: NC_002516.2

Gene: PA4536 Structure source: AlphaFold UniProt Q9HVP1

Export view

Amino acids 149

Annotations 3

Features 8

PDB binders 0

Druggability 0.37

Overview

Basic information about this protein and its source genome.

Accession: PA4536
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4536
Status: annotated
Amino acids: 149
Structure source: AlphaFold

GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030151 Binding to a molybdenum ion (Mo). GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.37

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0030151 Binding to a molybdenum ion (Mo).
GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
1	146	Gene3D	G3DSA:2.40.33.20	-
2	145	PANTHER	PTHR36930	METAL-SULFUR CLUSTER BIOSYNTHESIS PROTEINS YUAD-RELATED
17	143	ProSiteProfiles	PS51340	MOSC domain profile.
17	143	InterPro	IPR005302	Molybdenum cofactor sulfurase, C-terminal
39	140	Pfam	PF03473	MOSC domain
39	140	InterPro	IPR005302	Molybdenum cofactor sulfurase, C-terminal
4	143	SUPERFAMILY	SSF50800	PK beta-barrel domain-like
4	143	InterPro	IPR011037	Pyruvate kinase-like, insert domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4536	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.37
2				0.317