Target candidate with partial support; inspect missing evidence before prioritizing.
3 signalsStrengths
Risks / watch
How to read this page
PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.
AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.
ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.
pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.
FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.
Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.
PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.
ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.
ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.
LigQ / LigQ_2: an internal TPW pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.
Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.
DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.
Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.
EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.
KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.
Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.
Overview
Basic information about this protein and its source genome.
- Accession
- PA4541
- Gene
- PA4541
- Status
- annotated
- Amino acids
- 1417
- 3D evidence
- AlphaFold DB model
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Extracellular
Selected pocket evidence
The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
MNKSYTLVWNQATGCWNVASEGTRRRSKSGRGKALVVAGASLLGLFCQAPAFALPSGATVVSGDAGFQTSTDGRHMVIDQQSHKLITNWNEFSVRADERVSFHQPGQDAVALNRVIGRNGSDIQGRIDANGKVFLVNPNGVVFGKSAQVNVGGLVASTLDLADRDFLAGNYQFSGDSGATVSNAGSLQASEGGSIALLGARVSNDGLIQAQLGDVALGAGQGINLNFDGDGLLNLQVDKGSVDALAHNGGLIRADGGQVLMSARSADSLLKTVVNNQGTLEARTLRSAEGRIVLDGGEQGTVRVAGKQDASAIGGGNGGLVLNQGANVEIQRTAQVDTHADQGATGTWRILSHEVSVAAVGQANAAGDGSGQVHVAQGPAGANASDSNGVTIVQQQPAVDLAAGANGTSAVQSQSGANIGSGANGISVVQSQNSPNIGSGANGISVVQSQNGANIGAGASGISVVQSQNSPNIGSGVNGVTVVQSQNGANIGSGASGITVVQSQNGANIGSGASGISVVQSQSGPSIGSGVNGVTIVQSQSGANIGPGVSGIDVVQTQTLPNLSPGANGSSIVQVQTLPDIAADAGNVHVVQVQTGGNKVFGNSATNVRSRTVQARSNENVGSGLANPSSAGKGSTLHADTLARNLSTSNVEVVATRGNAHVGAPLSWDSGNGLTLTAERGDLRINGALTAQGENASLTLNAGQRPLRIDDSLSLTGQGARVEFNSDKGYALAEGTRITLSGKNAGFRANGRDYSVIQDLQQLRGIDRDLGGSYVLGNRIAGGNSSFLSIGNASAFGGTFDGLGNTIDNLAVYGTGAYSGLFSVNRGTLRNLNLERISADGAQATHYNVQVGSLAAVNLGRIDNVNASDIRIAAASKLNSLGGLVALNLGSIDNASASGTLVGNRHTYALGGLAAENISTARGVASISNSRADFAISGQLKDHASHYGAGGLVGRNRGGLIRSSGSQGTLSLSGHGMNLGGLVGYSSAGGLADVSASVDVSGNGQRGLYGGLIGLNVNSGIAHATASGKVRGTDAEALGGLIGRNLNAAINNASAHGDVSLQAGRYLGGLIGHNQAGNLANVSTSGNLSGGSLLQAGGLIGLNANASLVNASAKGNVATRGAEAVGGLLGENLYGSVINGSASGEVTDGSGKTLGGLIGSNLGGNHSNLKASGWVNAGANSDVGGLIGHNRGGNHSTLAASGNVTGGKGSRVGGLVGYNDAASLTNVSASGNVSASGSRAIGGLIGSDLRGSLMLASSHGIVNDKTSHNLGGLVGRGENTSIRSAKASGAVSGGAGIRAGGLVGSLEGWQALILGASAGGDVTAGYDSYIGGLVGFSTATISGASASGKVGGSGLLGGLVAWNQGNVMGSSASGRLEPQIPNQIHGGLIGINFGWQSWNSVYGAAATVPMIGRHYNL
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
1- GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 87 | 160 | NCBIfam | TIGR01901 | filamentous hemagglutinin family N-terminal domain |
| 87 | 160 | InterPro | IPR008638 | Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain |
| 55 | 1417 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 33 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 772 | 992 | Gene3D | G3DSA:2.160.20.110 | - |
| 54 | 389 | Gene3D | G3DSA:2.160.20.10 | - |
| 54 | 389 | InterPro | IPR012334 | Pectin lyase fold |
| 615 | 638 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 1 | 53 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM |
| 1035 | 1060 | Pfam | PF07581 | The GLUG motif |
| 1035 | 1060 | InterPro | IPR011493 | GLUG |
| 1209 | 1234 | Pfam | PF07581 | The GLUG motif |
| 1209 | 1234 | InterPro | IPR011493 | GLUG |
| 1121 | 1147 | Pfam | PF07581 | The GLUG motif |
| 1121 | 1147 | InterPro | IPR011493 | GLUG |
| 1257 | 1411 | Gene3D | G3DSA:2.160.20.110 | - |
| 1073 | 1193 | Gene3D | G3DSA:2.160.20.110 | - |
| 34 | 56 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 854 | PANTHER | PTHR12338 | AUTOTRANSPORTER |
| 52 | 301 | Pfam | PF05860 | TPS secretion domain |
| 52 | 301 | InterPro | IPR008638 | Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain |
| 1 | 48 | Pfam | PF13018 | Extended Signal Peptide of Type V secretion system |
| 1 | 48 | InterPro | IPR024973 | ESPR domain |
| 34 | 54 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 51 | 165 | SMART | SM00912 | Haemagg_act_2a |
| 51 | 165 | InterPro | IPR008638 | Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain |
| 45 | 339 | SUPERFAMILY | SSF51126 | Pectin lyase-like |
| 45 | 339 | InterPro | IPR011050 | Pectin lyase fold/virulence factor |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold DB
PA4541
|
AlphaFold DB | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 10 | 0.681 | ||||||
| 2 | 0.54 |