Protein profile

PA4555

type 4 fimbrial biogenesis protein PilY2

Genome: NC_002516.2

Gene: pilY2 CAZ10_23825 PA4555 ALP65_00677 PAERUG_P19_London_7_VIM_2_05_10_04540 Structure source: Experimental + AlphaFold UniProt Q51537 UniProt G3XD55
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Amino acids 115
Annotations 1
Features 10
PDB binders 0
Druggability 0.516

Overview

Basic information about this protein and its source genome.

Accession
PA4555
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pilY2 CAZ10_23825 PA4555 ALP65_00677 PAERUG_P19_London_7_VIM_2_05_10_04540
Status
annotated
Amino acids
115
Structure source
Experimental + AlphaFold
GO
GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.516
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
19 115 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
1 105 Pfam PF14481 Type 4 fimbrial biogenesis protein PilY2
1 105 InterPro IPR029497 Type 4 fimbrial biogenesis protein PilY2
18 98 Gene3D G3DSA:2.40.50.320 Copper binding periplasmic protein CusF
18 98 InterPro IPR042230 Copper binding periplasmic protein CusF superfamily
3 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 18 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
12 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3TDQ
X-ray 2.10 Å A,B
84.3% 19-115
PDBe RCSB PDBj File
Viewing
AlphaFold PA4555
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.516