Protein profile

PA4556

type 4 fimbrial biogenesis protein PilE

Genome: NC_002516.2

Gene: PAERUG_P19_London_7_VIM_2_05_10_04539 IPC1295_27365 fimA PA4556 pilE L4V69_31645 GUL26_14565 ALP65_00678 CAZ10_23830 GNQ48_15720 Structure source: Experimental + AlphaFold UniProt G3XD43 UniProt Q60148
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Amino acids 141
Annotations 4
Features 17
PDB binders 0
Druggability 0.627

Overview

Basic information about this protein and its source genome.

Accession
PA4556
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PAERUG_P19_London_7_VIM_2_05_10_04539 IPC1295_27365 fimA PA4556 pilE L4V69_31645 GUL26_14565 ALP65_00678 CAZ10_23830 GNQ48_15720
Status
annotated
Amino acids
141
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0043683 The assembly from its constituent parts of a type IV pilus. GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.627
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0043683 The assembly from its constituent parts of a type IV pilus.
  • GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
29 117 Pfam PF16732 Type IV minor pilin ComP, DNA uptake sequence receptor
29 117 InterPro IPR031982 Type IV pilus non-core minor pilin PilE-like
2 73 PANTHER PTHR30093 GENERAL SECRETION PATHWAY PROTEIN G
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 126 SUPERFAMILY SSF54523 Pili subunits
8 126 InterPro IPR045584 Pilin-like
1 6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8 140 FunFam G3DSA:3.30.700.10:FF:000002 Type 4 fimbrial biogenesis protein PilE
29 141 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 27 Pfam PF07963 Prokaryotic N-terminal methylation motif
3 27 InterPro IPR012902 Prokaryotic N-terminal methylation site
5 28 NCBIfam TIGR02532 prepilin-type N-terminal cleavage/methylation domain
5 28 InterPro IPR012902 Prokaryotic N-terminal methylation site
6 26 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site.
6 26 InterPro IPR012902 Prokaryotic N-terminal methylation site
7 28 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
8 139 Gene3D G3DSA:3.30.700.10 Glycoprotein, Type 4 Pilin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4NOA
X-ray 1.25 Å A
75.2% 36-141
PDBe RCSB PDBj File
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AlphaFold PA4556
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.627