Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4571
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4571
Status: annotated
Amino acids: 675
Structure source: AlphaFold

GO

GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.869

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records

Show feature table

Start	End	DB	Term	Name
1	7	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
8	18	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
24	156	SUPERFAMILY	SSF46626	Cytochrome c
24	156	InterPro	IPR036909	Cytochrome c-like domain superfamily
34	132	Pfam	PF00034	Cytochrome c
34	132	InterPro	IPR009056	Cytochrome c-like domain
1	23	SignalP_EUK	SignalP-noTM	SignalP-noTM
31	134	ProSiteProfiles	PS51007	Cytochrome c family profile.
31	134	InterPro	IPR009056	Cytochrome c-like domain
177	286	ProSiteProfiles	PS51007	Cytochrome c family profile.
177	286	InterPro	IPR009056	Cytochrome c-like domain
420	549	Gene3D	G3DSA:1.10.760.10	-
420	549	InterPro	IPR036909	Cytochrome c-like domain superfamily
552	659	SUPERFAMILY	SSF46626	Cytochrome c
552	659	InterPro	IPR036909	Cytochrome c-like domain superfamily
307	396	ProSiteProfiles	PS51007	Cytochrome c family profile.
307	396	InterPro	IPR009056	Cytochrome c-like domain
10	139	Gene3D	G3DSA:1.10.760.10	-
10	139	InterPro	IPR036909	Cytochrome c-like domain superfamily
19	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
560	653	ProSiteProfiles	PS51007	Cytochrome c family profile.
560	653	InterPro	IPR009056	Cytochrome c-like domain
300	419	Gene3D	G3DSA:1.10.760.10	-
300	419	InterPro	IPR036909	Cytochrome c-like domain superfamily
180	290	SUPERFAMILY	SSF46626	Cytochrome c
180	290	InterPro	IPR036909	Cytochrome c-like domain superfamily
435	539	SUPERFAMILY	SSF46626	Cytochrome c
435	539	InterPro	IPR036909	Cytochrome c-like domain superfamily
24	675	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
311	392	Pfam	PF13442	Cytochrome C oxidase, cbb3-type, subunit III
311	392	InterPro	IPR009056	Cytochrome c-like domain
561	648	Pfam	PF13442	Cytochrome C oxidase, cbb3-type, subunit III
561	648	InterPro	IPR009056	Cytochrome c-like domain
311	416	SUPERFAMILY	SSF46626	Cytochrome c
311	416	InterPro	IPR036909	Cytochrome c-like domain superfamily
550	672	Gene3D	G3DSA:1.10.760.10	-
550	672	InterPro	IPR036909	Cytochrome c-like domain superfamily
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
654	675	MobiDBLite	mobidb-lite	consensus disorder prediction
458	654	PANTHER	PTHR35008	BLL4482 PROTEIN-RELATED
1	23	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4571	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.869
2				0.81

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
THJ	4V2K	D3RVD4	112.1 Da LogP -1.01 TPSA 57.2	✓ Ro5	✓ Clean	`[O-]S(=O)(=O)[S-]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA4571