Protein profile

PA4599

resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC

Genome: NC_002516.2

Gene: PA4599 mexC Structure source: AlphaFold UniProt G3XD25
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Amino acids 387
Annotations 5
Features 22
PDB binders 0
Druggability 0.839

Overview

Basic information about this protein and its source genome.

Accession
PA4599
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4599 mexC
Status
annotated
Amino acids
387
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.839
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
38 370 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
38 370 InterPro IPR006143 RND efflux pump, membrane fusion protein
281 373 Gene3D G3DSA:2.40.420.20 -
290 356 Pfam PF00529 Cation efflux system protein CusB domain 1
290 356 InterPro IPR043602 Cation efflux system protein CusB, domain 1
148 168 Coils Coil Coil
56 280 Gene3D G3DSA:2.40.30.170 -
97 170 FunFam G3DSA:1.10.287.470:FF:000002 Efflux RND transporter periplasmic adaptor subunit
62 206 Gene3D G3DSA:2.40.50.100 -
97 170 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 383 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
61 289 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
61 289 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
51 296 SUPERFAMILY SSF111369 HlyD-like secretion proteins
10 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
26 387 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
280 372 FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4599
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.839
3 0.73