Protein profile

PA4604

hypothetical protein

Genome: NC_002516.2

Gene: PA4604 Structure source: AlphaFold UniProt Q9HVI5
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Amino acids 334
Annotations 3
Features 16
PDB binders 0
Druggability 0.826

Overview

Basic information about this protein and its source genome.

Accession
PA4604
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4604
Status
annotated
Amino acids
334
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
45.946
Human E-value
1.45e-12
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.826
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
226 330 Gene3D G3DSA:3.30.1220.10 -
226 330 InterPro IPR036627 CobW-like, C-terminal domain superfamily
237 329 SUPERFAMILY SSF90002 Hypothetical protein YjiA, C-terminal domain
11 210 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
11 210 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
10 211 Gene3D G3DSA:3.40.50.300 -
10 211 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
6 331 PANTHER PTHR13748 COBW-RELATED
13 191 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain
13 191 InterPro IPR003495 CobW/HypB/UreG, nucleotide-binding domain
9 211 FunFam G3DSA:3.40.50.300:FF:000778 GTP-binding protein YjiA
237 330 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain
237 330 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal
13 208 CDD cd03112 CobW-like
237 331 SMART SM00833 CobW_C_3
237 331 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4604
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.404