Protein profile

PA4613

catalase

Genome: NC_002516.2

Gene: PA4613 katB Structure source: AlphaFold UniProt Q59635
Export view
Amino acids 513
Annotations 9
Features 42
PDB binders 9
Druggability 0.793

Overview

Basic information about this protein and its source genome.

Accession
PA4613
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4613 katB
Status
annotated
Amino acids
513
Structure source
AlphaFold
EC
1.11.1.6
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion. GO:0042744 The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
65.517
Human E-value
3.01e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.793
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0046872 Binding to a metal ion.
  • GO:0042744 The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
  • GO:0042542 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
  • GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 30 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
29 503 SUPERFAMILY SSF56634 Heme-dependent catalase-like
29 503 InterPro IPR020835 Catalase superfamily
30 513 Gene3D G3DSA:2.40.180.10 Catalase core domain
70 86 ProSitePatterns PS00438 Catalase proximal active site signature.
70 86 InterPro IPR024708 Catalase active site
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
34 411 Pfam PF00199 Catalase
34 411 InterPro IPR011614 Catalase core domain
1 30 SignalP_EUK SignalP-noTM SignalP-noTM
31 513 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34 414 SMART SM01060 Catalase_2
34 414 InterPro IPR011614 Catalase core domain
32 497 CDD cd08154 catalase_clade_1
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
391 407 MobiDBLite mobidb-lite consensus disorder prediction
30 503 FunFam G3DSA:2.40.180.10:FF:000002 Catalase
391 413 MobiDBLite mobidb-lite consensus disorder prediction
435 495 Pfam PF06628 Catalase-related immune-responsive
435 495 InterPro IPR010582 Catalase immune-responsive domain
357 365 ProSitePatterns PS00437 Catalase proximal heme-ligand signature.
357 365 InterPro IPR002226 Catalase haem-binding site
30 503 ProSiteProfiles PS51402 catalase family profile.
30 503 InterPro IPR018028 Catalase, mono-functional, haem-containing
25 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
47 70 PRINTS PR00067 Catalase signature
47 70 InterPro IPR018028 Catalase, mono-functional, haem-containing
109 127 PRINTS PR00067 Catalase signature
109 127 InterPro IPR018028 Catalase, mono-functional, haem-containing
344 370 PRINTS PR00067 Catalase signature
344 370 InterPro IPR018028 Catalase, mono-functional, haem-containing
130 147 PRINTS PR00067 Catalase signature
130 147 InterPro IPR018028 Catalase, mono-functional, haem-containing
149 167 PRINTS PR00067 Catalase signature
149 167 InterPro IPR018028 Catalase, mono-functional, haem-containing
312 339 PRINTS PR00067 Catalase signature
312 339 InterPro IPR018028 Catalase, mono-functional, haem-containing
29 496 PANTHER PTHR11465 CATALASE
29 496 InterPro IPR018028 Catalase, mono-functional, haem-containing
24 503 PIRSF PIRSF038928 Catalase_clade1-3
24 503 InterPro IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4613
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.793

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

10 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3TR
1TH4
P00432 84.1 Da LogP -0.61 TPSA 67.6 ✓ Ro5 ✓ Clean c1[nH]nc(n1)N
AZI
1TH2
P00432 42.0 Da LogP 0.87 TPSA 58.7 ✓ Ro5 Alert [N-]=[N+]=[N-]
H2S
3P9Q
P21179 34.1 Da LogP 0.11 TPSA 0.0 ✓ Ro5 ✓ Clean S
HDD
1GGE
P21179 632.5 Da LogP 3.21 TPSA 101.9 1 viol. ✓ Clean Cc1c2n3c(c1CCC(=O)O)C=C4[C@]5(CCC(=O)O5)[C@@](C…
HDE
3P9Q
P21179 638.5 Da LogP 4.58 TPSA 101.9 1 viol. ✓ Clean CCc1c(c2n3c1Cc4c(c(c5n4[Fe]36n7c(c(c(c7C=C8N6C(…
NH3
3RGS
P00432 17.0 Da LogP 0.16 TPSA 35.0 ✓ Ro5 ✓ Clean N
O
1GWF
P29422 18.0 Da LogP -0.82 TPSA 31.5 ✓ Ro5 ✓ Clean O
OXY
1QWL
P77872 32.0 Da LogP 0.07 TPSA 34.1 ✓ Ro5 ✓ Clean O=O
PEO
1GGF
P21179 34.0 Da LogP 0.02 TPSA 40.5 ✓ Ro5 ✓ Clean OO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.